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Natural Product Research
Formerly Natural Product Letters
Volume 29, 2015 - Issue 8
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Articles

A new isoquinoline alkaloid with anti-microbial properties from Berberis jaeschkeana Schneid. var. jaeschkeana

Muhammad AlamzebInstitute of Chemical Sciences, University of Swat, Swat19130, PakistanCorrespondence[email protected] [email protected]
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,
M. Rafiullah KhanPhytopharmaceutical and Neutraceutical Research Laboratories (PNRL), Institute of Chemical Sciences, University of Peshawar, Peshawar, PakistanView further author information
,
Mamoon-Ur-RashidDepartment of Chemistry, University of Poonch Rawalakot, AJK, Poonch, PakistanView further author information
,
Saqib AliUniversity of Swabi, Swabi, PakistanView further author information
&
Ashfaq Ahmad KhanPhytopharmaceutical and Neutraceutical Research Laboratories (PNRL), Institute of Chemical Sciences, University of Peshawar, Peshawar, PakistanView further author information
Pages 692-697 | Received 16 Sep 2014, Accepted 21 Oct 2014, Published online: 25 Nov 2014
 
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Abstract

One new isoquinoline alkaloid named berberidione (1) along with four new source alkaloids berberine (2), palmatine (3), jatrorrhizine (4) and chondrofoline (5) and three new source non-alkaloids syringic acid (6), β-sitosterol (7) and stigmasterol (8) was isolated and characterised from different fractions of Berberis jaeschkeana Schneid var. jaeschkeana. All the structures were determined from 1D and 2D spectroscopic data. Crude extract, sub-fractions and isolated compounds showed excellent anti-microbial properties. The toxicity level for the alkaloids was found to be very low on THP-1 cells.

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Funding

We are sincerely thankful to the Higher Education Commission of Pakistan for their financial support for our research work and studies.

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