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Abstract
Enterobacter cloacae is a versatile bacterial species inhabiting a wide variety of niches and is capable of metabolising a wide variety of substances as energy resources. The fermentation culture of this bacterial species has successfully yielded one new compound, Rimboxa (1) and three known compounds, i.e. indole-3-carboxaldehyde (2), indole-3-acetic acid (3) and 3,4-di-t-butylaniline (4). Rimboxa (1) is shown to possess the 1,2-oxathiolane core structure. 3,4-Di-t-butylaniline (4) is isolated for the first time from a natural resource. These compounds were isolated and characterised using extensive chromatographic and spectroscopic methods, and were subjected to cytotoxicity evaluations.
Additional information
Funding
This work was supported by the University of Malaya UMRG [grant number RG094/10AFR], [grant number RP002A-13Bio]; University of Malaya HIR [grant number UM.C/625/1/HIR/043]; Government of Malaysia MOSTI E-science fund [grant number SF004-2014] and Postgraduate Research Fund of University Malaya [grant number PG027-2012B].