Ascomycotin A, a new citromycetin analogue produced by Ascomycota sp. Ind19F07 isolated from deep sea sediment

Abstract

A new citromycetin analogue, ascomycotin A (1), together with eight known compounds, wortmannilactone E (2), orcinol (3), orsellinic acid (4), isosclerone (5), (3R,4S)-( − )-4-hydroxymellein (6), diorcinol (7), chaetocyclinone B (8) and 2,5-dimethoxy-3,6-di(p-methoxypheny1)-1,4-benzoquinone (9), was isolated from the fungal strain Ascomycota sp. Ind19F07, which was isolated from the deep sea sediment of the Indian Ocean. The structures of the compounds were established by spectroscopic data including 1D and 2D NMR and HR-ESI-MS. Compounds (1–9) were evaluated for antibacterial activity.

Keywords::

• fungi
• deep sea sediment
• citromycetin analogue
• spectroscopy

Notes

^1. The first two authors contributed equally to this work.

Additional information

Funding

This work was supported financially by the National Key Basic Research Program of China (973 Project), [grant number 2011CB915503]; the National High Technology Research and Development Program (863 Program), [grant number 2012AA092104]; the National Natural Science Foundation of China [grant number 52102308], [grant number 31270402], [grant number 20902094], [grant number 41176148], [grant number 21002110]; the Strategic Priority Research Program of the Chinese Academy of Sciences [grant number XDA11030403]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [grant number GD2012-D01-001]; and Guangzhou scientific research project of 2014 [grant number 2014J4100212].