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Natural Product Research
Formerly Natural Product Letters
Volume 29, 2015 - Issue 9
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Articles

Sassarandainol: a new neolignan and anti-inflammatory constituents from the stem of Sassafras randaiense

Ya-Ling HouGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan, ROCView further author information
,
Hsun-Shuo ChangGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan, ROC;School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan, ROCView further author information
,
Hui-Chun WangGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan, ROCView further author information
,
Sheng-Yang WangDepartment of Forestry, National Chung Hsing University, Taichung402, Taiwan, ROCView further author information
,
Tze-Ying ChenNational Ilan University, Ilan260, Taiwan, ROCView further author information
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Chu-Hung LinSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan, ROCView further author information
&
Ih-Sheng ChenGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan, ROC;School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung807, Taiwan, ROCCorrespondence[email protected]
View further author information
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Pages 827-832 | Received 13 Aug 2014, Accepted 10 Nov 2014, Published online: 11 Dec 2014
 
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Abstract

A new neolignan, (R)-( − )-sassarandainol (1), together with 10 known compounds (2–11), was isolated from the stem of Sassafras randaiense. The structures were determined by spectroscopic techniques. Among these isolates, γ-tocopherol (5), subamolide B (7) and β-sitosterone (9) exhibited moderate iNOS inhibitory activity on nitrite production induced (%) value of 30.51, 28.68 and 16.96, respectively.

Additional information

Funding

This work was supported by a grant [grant number NSC101-2320-B-037-030] from the National Science Council, Republic of China and the Kaohsiung Medical University Research Foundation [grant number KMUER013].

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