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Natural Product Research
Formerly Natural Product Letters
Volume 29, 2015 - Issue 22
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Short Communication

Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum

Sylvia D.F. SouzaDepartment of Pharmacy, Federal University of Sergipe, Av. Marechal Rondon, s/n, Rosa Elze, CEP 49.100-000, São Cristovão, Sergipe, BrazilView further author information
,
Carolina S.L. FrancaDepartment of Pharmacy, Federal University of Sergipe, Av. Marechal Rondon, s/n, Rosa Elze, CEP 49.100-000, São Cristovão, Sergipe, BrazilView further author information
,
Edenilson S. NiculauDepartment of Chemistry, Federal University of Sergipe, Sergipe, BrazilView further author information
,
Larissa C.B. CostaAgriculture Department, Federal University of Lavras, Campus Universitário, Lavras, Minas Gerais, BrazilView further author information
,
José E.B. PintoAgriculture Department, Federal University of Lavras, Campus Universitário, Lavras, Minas Gerais, BrazilView further author information
,
Péricles B. AlvesDepartment of Chemistry, Federal University of Sergipe, Sergipe, BrazilView further author information
&
Rosilene M. MarçalDepartment of Pharmacy, Federal University of Sergipe, Av. Marechal Rondon, s/n, Rosa Elze, CEP 49.100-000, São Cristovão, Sergipe, BrazilCorrespondence[email protected]
View further author information
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Pages 2125-2128 | Received 14 Aug 2014, Accepted 13 Nov 2014, Published online: 06 Jan 2015
 
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Abstract

Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100 μM), BaCl2 (0.03 M) and low- and high-K+ concentrations (25 and 60 mM, respectively). OS shifted the concentration–response curve for calcium to the right in a parallel manner. GC/MS analysis showed that OS consists mostly of methyl chavicol (97.57%). These results suggest that OS antispasmodic effect is mediated through calcium channel blockade. In addition, OS effect and mode of action could be accounted for methyl chavicol.

Additional information

Funding

This work was financially supported by grants and fellowships of Conselho Nacional de Desenvolvimento Científico e Tecnológico (PIBIC.2008) of the Brazilian Ministry of Science and Technology.

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