Biotransformation of agallochaexcoerin A by Aspergillus flavus

Abstract

Agallochaexcoerin A (1), a seco-manoyl oxide diterpenoid was metabolised by pathogenic fungus, Aspergillus flavus, in growth media to yield a new metabolite, termed agallochaexcoerin G (2). It was confirmed by using IR, UV, ¹H NMR and HR-ESI-MS techniques. This microbial bioconversion was achieved by unusual dehydration at C-4 position.

Keywords::

• Agallochaexcoerin A
• Aspergillus flavus
• pathogenic fungus
• biotransformation
• microbial dehydration

Acknowledgements

We are highly indebted to the Department of Science and Technology (DST) for financial support.