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Natural Product Research
Formerly Natural Product Letters
Volume 29, 2015 - Issue 9
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Articles

Geissoschizine methyl ether N-oxide, a new alkaloid with antiacetylcholinesterase activity from Uncaria rhynchophylla

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Pages 842-847 | Received 30 Sep 2014, Accepted 16 Nov 2014, Published online: 13 Dec 2014
 

Abstract

Geissoschizine methyl ether N-oxide, a new oxindole alkaloid, along with 14 known alkaloids, was isolated from the aerial part of Uncaria rhynchophylla. Their structures were identified by comprehensive spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that the new compound exhibited anti-AChE activity with IC50 value of 23.4 μM.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [number U0932602] and the National Basic Research Program of China [973 Program No. 2011CB915503].

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