A new flavonoid from Cudrania cochinchinensis

Abstract

Chemical investigation of the ethanol extract of the roots of Cudrania cochinchinensis led to the isolation of a new flavonoid, (6S,12S,13R)-1-methoxy cyanomaclurin (1), together with seven known compounds, 1,3,5-trihydroxy-4-(3′-hydroxy-3′-methylbutyl)xanthone (2), 1,3,6-trihydroxy-4-prenylxanthone (3), 1,3,6,7-tetrahydroxyxanthone (4), 1,3,5,6-tetrahydroxyxanthone (5), 1,3,6-trihydroxy-5-methoxyxanthone (6), resveratrol (7) and oxyresveratrol (8). The structure of compound 1 was elucidated on the basis of 1D and 2D NMR spectra and the HR-ESI-MS data. The absolute stereochemistry was deduced via Rh₂(OCOCF₃)₄-induced CD and NOESY spectra.

Keywords::

• Cudrania cochinchinensis
• flavonoid
• (6S
• 12S
• 13R)-1- methoxycyanomaclurin

Acknowledgements

We gratefully acknowledge Mrs Yan Xue and Mrs Mei-Feng Xu (the National Center of Biomedical Analysis) for the measurements of the MS and NMR spectra. We also thank Mrs Pei-Pei Yang (Institute of Materia Medica, Chinese Academy of Medical Sciences) for the measurements of the CD and Rh₂(OCOCF₃)₄-induced CD spectra.

Notes

^1. These authors contributed equally to this work.