A new aromatic glucoside from stem bark of Illicium difengpi K.I.B. et K.I.M.

Abstract

A new aromatic glucoside, namely 4-methoxyphenyl-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (1), together with six known aromatic glucosides (2–7) were isolated from the stem bark of Illicium difengpi. The structures of these compounds were established by spectroscopic methods. The isolated aromatic glucosides were tested for anti-inflammatory activity. Compounds 1, 3 and 6 showed significant inhibitory effect on nuclear factor kappa B (NF-κB) in RAW 264.7 macrophages induced by lipopolysaccharide.

Keywords::

• Illicium difengpi
• anti-inflammatory
• aromatic glucoside

Additional information

Funding

This work was supported by the National Natural Science Foundation of the People's Republic of China [grant number 81274032], [grant number 81325024]; the Scientific Foundation of Shanghai [grant number 11DZ1971301].