New sesquiterpenoid derivatives from Solanum septemlobum with cytotoxicities

Abstract

Two new sesquiterpenoid derivatives, attributable to eudesmane-type (1–2, named septemlobin D and 11,12-O-isopropylidenesolajiangxin F), were isolated from the whole plant of Solanum septemlobum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D-NMR (¹H–¹H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoid derivatives were found to show significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC₅₀ values in the range of 3.0–7.3 μM.

Keywords::

• Solanum septemlobum
• Solanaceae
• sesquiterpenoid
• septemlobin D
• 11,12-O-isopropylidenesolajiangxin F
• cytotoxic activity

Acknowledgements

The authors are grateful to Ms. Wen-Yan Wang, Li Shen (School of Pharmaceutical Science, Yantai University) for the measurements of FAB-MS, HR-FAB-MS, UV, IR and NMR spectra, respectively. The authors also gratefully acknowledge Mr. Hong-Bo Wang (School of Pharmaceutical Science, Yantai University) for the bioactivity screenings.

Additional information

Funding

This study was financially supported by the Natural Science Foundation of China [grant number 21372189] and Natural Science Foundation of Shandong Province [grant number ZR2013HM023].