A new labdane diterpene from the rhizomes of Alpinia officinarum

Abstract

A new labdane diterpene, (Z)-12,14-labdadien-15(16)-olide-17-oic acid (1), and a new natural cadinane sesquiterpene, 4-isopropyl-6-methyl-1-naphthalenemethanol (2), were isolated from the ethanolic extract of the rhizomes of Alpinia officinarum, together with three other products, galangin (3), kaempferol (4) and quercetin (5). Their structures were elucidated by using extensive spectroscopic methods. Compounds 1 and 2 showed no remarkable cytotoxic activity against HeLa and HepG2 cancer cell lines with IC₅₀>50 μg mL^− 1.

Keywords:

• Alpinia officinarum
• labdane diterpene
• cadinane sesquiterpene

Additional information

Funding

This work was financially supported by Science and Technology Project of Hunan Province [grant number 2012FJ4293]; University Industrialization Cultivation Project of Hunan Province [grant number 11CY013].