A new flavonol glycoside from the florets of Carthamus tinctorius L.

Abstract

One new flavonol glycoside, 6-hydroxykaempferol-3-O-β-D-glucoside-7-O-β-D-glucuronide (1), together with eight known flavonoids and three known quinochalcones, was isolated from the florets of Carthamus tinctorius L. Their structures were determined by extensive spectroscopic analyses. Their cardioprotective effects against H₂O₂-induced apoptosis in H9c2 cells were also evaluated; compounds 1, 2, 4–5, 7–10 and 12 provided significant protective effects on H₂O₂-induced H9c2 cells at the concentration of 25 μg/mL.

Keywords:

• Carthamus tinctorius L
• cardioprotective activitiy
• 6-hydroxykaempferol-3-O-β-D-glucoside-7-O-β-D-glucuronide

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support from the National Science and Technology Major Project ‘Key New Drug Creation and Manufacturing Program’ [grant number 2013ZX09402203] of the People's Republic of China is gratefully acknowledged.