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Abstract
Two new monoterpenoid indole alkaloids, named 14,15-dihydro-14β,15β-epoxy-10-hydroxyscandine (1) and 15α-hydroxy-meloscandonine (2), together with 12 known compounds, were isolated from the aerial parts of Melodinus hemsleyanus Diels. The structures of 1 and 2 were elucidated on the bases of 1D and 2D NMR spectra and MS. Two new compounds were evaluated for their PTP1B and Drak2 inhibitory effects, and inactivity.
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Acknowledgements
We thank Prof. Jia Li at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences for the evaluation of PTP1B and Drak2 inhibition activity.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Funding
This work was financially supported by National Natural Science Foundation of China [grant number 20932007], [grant number 21172214] and National New Drug Innovation Major Project of China [grant number 2011ZX09307-002-02].