New phenyl derivatives from endophytic fungus Botryosphaeria sp. SCSIO KcF6 derived of mangrove plant Kandelia candel

Abstract

Two new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 1–7 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC₅₀ value of 1.12 μM.

Keywords:

• endophytic fungus
• Botryosphaeria sp. SCSIO KcF6
• COX-2 inhibitory activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

^1. The first two authors contributed equally to this work.

Additional information

Funding

This work was financially supported by the National Key Basic Research Program of China (973)'s Project [grant number 2011CB915503]; the National Natural Science Foundation of China [grant number 21202177], [grant number 41406187], [grant number 21172094], [grant number 41376155] and [grant number 2137210]; Strategic Priority Research Program of the Chinese Academy of Sciences [grant number XDA11030403]; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [grant number GD2012-D01-001] and Guangzhou Scientific Research Project [grant number 2014J4100212].