A review on biological sources, chemistry and pharmacological activities of pinostrobin

Abstract

Pinostrobin, a dietary bioflavonoid discovered more than 6 decades ago in the heart-wood of pine (Pinus strobus), has depicted many pharmacological activities including anti-viral, anti-oxidant, anti-leukaemic, anti-inflammatory and anti-aromatase activities. It is an inhibitor of sodium channel and Ca²⁺ signalling pathways and also inhibits intestinal smooth muscle contractions. In spite of the fact that pinostrobin has an application as functional foods, till-to-date no comprehensive review on pinostrobin has been carried out. Hence, the present review deals with the biological sources, chemistry and pharmacological activities of pinostrobin.

Graphical abstract

Keywords:

• Pinostrobin
• flavanones
• anti-inflammatory
• anti-cancer
• anti-viral
• functional foods

Acknowledgements

NKP and GJ thanks the Director, NIPER, SAS Nagar, India, for providing the facilities for the present review study. NKP was DST-Inspire Fellow, India, for PhD, and GJ was a recipient of NIPER fellowship (2013–2015) for master programme during the course of present study.

Disclosure statement

No potential conflict of interest was reported by the authors.