New α-glucosidase inhibiting anthracenone from the barks of Harungana madagascariensis Lam

Abstract

Two new 10-hydroxy-9(10H)-anthracenone, madagascenone A (1) and B (2), were isolated from the barks of Harungana madagascariensis Lam. The structures of the compounds were determined using 1D- and 2D-NMR and mass spectroscopic techniques. Both of the compounds showed an in vitro α-glucosidase inhibition with IC₅₀ = 69.9 ± 4.21 and 122.3 ± 1.13 μM, respectively, more potent than the standard acarbose (IC₅₀ = 840 ± 1.23 μM).

Keyword:

• Harungana madagascariensis
•  madagascenone A and B
• α-glucosidase inhibition

Acknowledgements

Mr Ismail B. Onajobi is grateful to the Academy of Sciences for the Developing World (TWAS) for the fellowship to pursue research at the H. E. J. Research Institute of Chemistry (International Center for Chemical and Biological Sciences), University of Karachi, Pakistan.

Disclosure statement

The authors declare that there is no conflict of interest.