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Natural Product Research
Formerly Natural Product Letters
Volume 30, 2016 - Issue 15
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Research Article

A new epidioxy-tetracyclic triterpenoid from Poria cocos Wolf

Shiping LiJiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang, People’s Republic of China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People’s Republic of China
,
Zhixin WangKey Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, People’s Republic of China
,
Rui GuJiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang, People’s Republic of China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People’s Republic of China
,
Yiwu ZhaoJiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang, People’s Republic of China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People’s Republic of China
,
Wenzhe HuangJiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang, People’s Republic of China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People’s Republic of China
,
Zhenzhong WangJiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang, People’s Republic of China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People’s Republic of China
&
Wei XiaoJiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang, People’s Republic of China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1712-1717 | Received 06 Sep 2015, Accepted 21 Nov 2015, Published online: 03 Feb 2016
 
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Abstract

A new epidioxy-tetracyclic triterpenoid, 3-(2-hydroxyacetoxy)-5α, 8α-peroxydehydrotumulosic acid (10), along with nine known compounds were isolated from Poria cocos Wolf (Polyporaceae). Their structures were determined by extensive spectroscopic analyses and comparison with literature data. The cytotoxicity of these compounds against human cancer cell lines MNK-45 was evaluated by MTT method.

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This work was supported by the National Science and Technology Major Project ‘Key New Drug Creation and Manufacturing Program’ [grant number 2013ZX09402203] of the People’s Republic of China.

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