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Abstract
Fifty-eight phenolic compounds isolated from Phyllanthus emblica were screened and compared for their in vitro and in vivo antioxidant properties, as well as hyaluronidase (HAase) inhibitory activities. Among them, 20 compounds showed to be promising antioxidants due to the stronger scavenging activity in both DPPH radical and Danio rerio reactive oxygen species assays, while nine compounds were potential HAase inhibitors with 100-fold stronger activities than that of the positive control, DSCG. The structure activity relationship was discussed.
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This work was supported by the NSFC [grant number 21002105], [grant number 81473121]; the 12th Five Year National Science & Technology Supporting Program [grant number 2012BAI29B06]; the National Science and Technology Support Program of China [grant number 2013BAI11B02]; the Fourteenth Candidates of the Young Academic Leaders of Yunnan Province (Min XU) [grant number 2011CI044]; the West Light Foundation of the Chinese Academy of Sciences.