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Abstract
Two new polyhydroxylated triterpenoids were isolated from the acetone extract of the aerial parts of Salvia urmiensis Bunge. Their structures were elucidated by 1D and 2D NMR and HR-ESI-MS analyses as olean-12-ene-1β,3β,11α,22α-tetraol (1) and urs-12-ene-1β,3β,11β,22α-tetraol (2). The effect of these compounds on cell viability of MCF-7 cells was investigated by the MTT assay. Compounds 1 and 2 showed weak cytotoxicity with IC50 values of 110.23 ± 0.12 and 88.35 ± 0.09 μM, respectively.
Graphical abstract
Acknowledgements
Financial support by the Shahid Beheshti University Research Council is gratefully acknowledged. All spectra were performed at the Department of Pharmaceutical Sciences, Division of Pharmaceutical Biology, University of Basel. The kind assistance of Prof M. Hamburger, Dr S.N. Ebrahimi, and all other staff is gratefully appreciated.
Disclosure statement
No potential conflict of interest was reported by the authors.