Penimethavone A, a flavone from a gorgonian-derived fungus Penicillium chrysogenum

Abstract

A novel flavone, penimethavone A (1), possessing a rare unique methyl group at ring-B, was isolated from the fungus Penicillium chrysogenum cultured from a gorgonian Carijoa sp. collected from the South China Sea. The structure was elucidated by extensive spectroscopic analysis and by comparison with related known compound. Compound 1 showed selective and moderate cytotoxicity against cervical cancer (HeLa) and rhabdomyosarcoma cell lines with IC₅₀ values of 8.41 and 8.18 μM, respectively.

Keywords:

• Penicillium chrysogenum
• gorgonian Carijoa sp
• flavone
• cytotoxicity

Funding

This work was supported by the Program of National Natural Science Foundation of China [grant number 41322037]; Program of Natural Science Foundation of Shandong Province of China [grant number JQ201510]; and Marine Special Public Welfare Scientific Research, State Oceanic Administration of China [grant number 201405038].