A new Secondary metabolites of the crinoid (Comanthina schlegeli) associated fungus Alternaria brassicae 93

Abstract

Fungus Alternaria brassicae 93 isolated from crinoid (Comanthina schlegeli), which was collected from the South China Sea. Six compounds were isolated from A. brassicae 93, including one new compound (1), along with five known compounds, ochratoxin A methyl ester (2), cis-4-hydroxym-ellein (3), (R)-7-hydroxymellein (4), trans-2-anhydromevalonic (5) and protocatechuic acid (6). Their structures were determined by spectroscopic methods and comparison with reported data. Cytotoxicity against two human cancer cell lines and antibacterial activity against twelve aquatic bacteria of compound 1 were also tested.

The fungus Alternaria brassicae 93 separated from crinoid (Comanthina schlegeli) produced one new compound (1).

Keywords:

• Crinoid
• Alternaria brassicae
• associated fungus
• secondary metabolites

Acknowledgements

We would like to acknowledge Instrumental Analysis and Research Center of Sun Yat-Sen University for assistance in acquisition of mass spectra and NMR data.

Funding

This work was supported by the National Natural Science Foundation of China [grant number 21272286]; China’s Marine Commonweal Research Project [grant number 201305017].