Biologically active new metabolites from a Florida collection of Moorea producens

Abstract

A bioassay-guided investigation (cancer cell cytotoxicity) of a Moorea producens collection from Key West, Florida, led to the discovery of two new bioactive natural products [(+)-malyngamide Y and a cyclic depsipeptide, (+)-floridamide]. Their planar structures were deduced through extensive analysis of 1D and 2D NMR spectroscopic data and supported by HRFAB mass spectrometry. The new cyclic depsipeptide contains four amino acids units, including N-methyl phenylalanine, proline, valine and alanine, beside the unique unit, 2,2-dimethyl-3-hydroxy-octanoic acid. In addition to the discovery of these two new compounds, two previously reported metabolites were also isolated and identified from this cyanobacterial collection; (−)-C-12 lyngbic acid and the antibacterial agent (−)-malyngolide.

Keywords:

• Moorea producens
• cytotoxicity
• malyngamide
• floridamide

Acknowledgement

We gratefully acknowledge Jeff. Moore (Chemistry, OSU) for mass spectral data and the Government of Florida State for permission to make these collections.