The structure proposed for apteniol D is different from that of the compound obtained by total synthesis

Abstract

We describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N-dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D.

Keywords:

• Aptenia cordifolia
• diphenyl ether
• Ullmann ether synthesis
• apteniol

Acknowledgement

The authors would like to thank Enago (www.enago.jp) for the English language review.