Three new phenylpropanoids from Lavandula angustifolia and their bioactivities

Abstract

Three new phenylpropanoids, 3-(3,4-dimethoxy-5-methylphenyl)-3-oxopropyl acetate (1), 3-hydroxy-1-(3,4-dimethoxy-5-methylphenyl)propan-1-one (2), and 3-hydroxy-1-(4-methylbenzo[d][1,3]dioxol-6-yl) propan-1-one (3), together with three known phenylpropanoids (4–6) were isolated from the whole plant of Lavandula angustifolia. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–6 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 1–3 showed high anti-TMV activity with inhibition rate of 35.2, 38.4 and 33.9%. These rates are higher than that of positive control. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 26.8–28.9%, respectively. Compounds 1–6 also showed weak inhibitory activities against some tested human tumour cell lines with IC50 values in the range of 3.8–8.8 μM.

Keywords:

• Lavandula angustifolia
• phenylpropanoids
• anti-tobacoo mosaic virus activities
• cytotoxicity activities