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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 12
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Research Articles

Two new phenylpropanoids from Swertia atroviolacea and their anti-5α-reductase activity

Hai-Yan WuKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. China
,
Xue-Qing KanKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. China
,
Yu ShengKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. China
,
Lin-Yun MouKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. China
,
Qing-Song YangKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. China
,
Qiu-Feng HuKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. ChinaCorrespondence[email protected]
&
Gan-Peng LiKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. ChinaCorrespondence[email protected]
 show all
Pages 1431-1436 | Received 25 Sep 2016, Accepted 01 Nov 2016, Published online: 05 Dec 2016
 
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Abstract

Two new phenylpropanoids (1–2), together with two known lignans (3–4), were isolated from whole herb of Swertia atroviolacea. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. Compounds 1 and 2 were evaluated for their anti-5α-reductase activity. The results revealed that 1 and 2 showed weak activity with reductase inhibitions of 45.6 ± 2.8% and 38.4 ± 2.5%, respectively.

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