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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 13
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Research Articles

A new monoterpenoid indole alkaloid from Ochrosia elliptica

A-Hong ChenCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
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Qing-Long LiuCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
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Yan-Lei MaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
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Zhi-Hua JiangCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
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Jin-Ying TangCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
,
Yan-Ping LiuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
,
Guang-Ying ChenCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China
,
Yan-Hui FuCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. ChinaCorrespondence[email protected]
&
Wei XuCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P. R. ChinaCorrespondence[email protected]
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Pages 1490-1494 | Received 26 Sep 2016, Accepted 10 Dec 2016, Published online: 09 Jan 2017
 
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Abstract

A new monoterpenoid indole alkaloid, 10-methoxyakuammidine (1), together with four known alkaloids (2–5), were isolated from the stems and leaves of Ochrosia elliptica. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. 1 exhibited inhibitory effects with IC50 values comparable to those of cisplatin.

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