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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 18
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Research Articles

A new indole alkaloid with anti-inflammatory activity from Nauclea officinalis

Qing-Long LiuCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China
,
A-Hong ChenCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China
,
Jin-Ying TangCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China
,
Yan-Lei MaCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China
,
Zhi-Hua JiangCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China
,
Yan-Ping LiuKey Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China
,
Guang-Ying ChenCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China
,
Yan-Hui FuCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. China;Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. ChinaCorrespondence[email protected]
&
Wei XuCollege of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, P.R. ChinaCorrespondence[email protected]
 show all
Pages 2107-2112 | Received 30 Sep 2016, Accepted 10 Dec 2016, Published online: 09 Jan 2017
 
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Abstract

A new indole alkaloid, 17-O-methyl-19-(Z)-naucline (1), together with seven known alkaloids (2–8), were isolated from the stems and leaves of Nauclea officinalis. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literature. 17-O-methyl-19-(Z)-naucline (1) showed significant inhibitory activity on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro with an IC50 value of 3.6 μM.

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