A phytotoxic bicyclic lactone and other compounds from endophyte Xylaria curta

Abstract

A new compound, (3aS,6aR)-4,5-dimethyl-3,3a,6,6a-tetrahydro-2H-cyclopenta [b]furan-2-one (2), along with two known metabolites, myrotheciumone A (1) and 4-oxo-4H-pyron-3-acetic acid (3) was isolated from the ethyl acetate extract of fermentation broth of Xylaria curta 92092022. The structures of these compounds were elucidated on the basis of spectroscopic methods (UV, IR, HRESITOFMS, 1D NMR, and 2D NMR). Compounds 1 and 2 showed moderate antibacterial and phytotoxic activities.

Keywords:

• Endophyte
• Xylaria curta
• myrotheciumone A
• cyclopenta[b]furan
• antimicrobial activity
• phytotoxicity

Acknowledgement

One of us (A.T) thanks the JSPS RONPAKU (Dissertation PhD, ID: R11516) Program for financial support.