Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 22
Submit an article Journal homepage
226
Views
8
CrossRef citations to date
0
Altmetric
Research Articles

Cytotoxicity of flavonoids and isoflavonoids from Crotalaria bracteataFootnote

Sukanda SudanichNatural Products Research Unit, Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand
,
Suppachai TiyaworanantFaculty of Pharmaceutical Sciences, Department of Pharmacognosy and Toxicology, Khon Kaen University, Khon Kaen, Thailand
&
Chavi YenjaiNatural Products Research Unit, Faculty of Science, Department of Chemistry, Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, ThailandCorrespondence[email protected]
Pages 2641-2646 | Received 24 Nov 2016, Accepted 15 Jan 2017, Published online: 13 Feb 2017
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

A new flavonoid, crotakanda (1), and seven known compounds including a flavonoid, four isoflavonoids, a pterocarpan and a cinnamaldehyde were isolated from the stems and roots of Crotalaria bracteata. Their structures were elucidated by a combination of spectroscopic methods. Compound 2 showed cytotoxicity against MCF-7 with an IC50 value of 79.90 μM whereas 2 and 4 exhibited cytotoxicity against the NCI-H187 cell line with IC50 values of 71.57 and 95.47 μM, respectively.

Acknowledgements

We thank Khon Kaen University and the Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education for partial support. The Bioassay Laboratory of the National Center for Genetic Engineering and Biotechnology, Pathumthani, Thailand, is gratefully acknowledged for biological activity assays.

Notes

In remembrance of His Majesty King Bhumibol Adulyadej (1927–2016).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.