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Natural Product Research
Formerly Natural Product Letters
Volume 31, 2017 - Issue 24
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Research Article

A new immunosuppressive pregnane glycoside from aqueous fraction of Epigynum cochinchinensis

Zong WanKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of China
,
Yuan-Cheng YaoKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of China
,
Fei GaoKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of China
,
Sheng-Bao CaiKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of China
,
Afsar KhanDepartment of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan
,
Tian-Rui ZhaoKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of China
,
Xiao-Yan YangFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People’s Republic of China
,
Jian FanKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of China
,
Sheng-Yan QianGuizhou Key Laboratory of Characteristic Microbial Research & Drug Development, Zunyi Medical University, Zunyi, People’s Republic of China
,
Jian-Xin CaoKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of ChinaCorrespondence[email protected]
&
Gui-Guang ChengKunming University of Science and Technology, Yunnan Institute of Food Safety, Kunming, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 2893-2899 | Received 05 Dec 2016, Accepted 08 Mar 2017, Published online: 31 Mar 2017
 
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Abstract

Chemical investigation on the aqueous fraction of the stems of Epigynum cochinchinensis led to the isolation of a new pregnane glycoside named as epigycoside A (1) along with three known analogues (2–4). The structure of compound 1 was elucidated by means of spectroscopic techniques, including HRESIMS, and 1D and 2D NMR experiments. The immunosuppressive activity of 1 was evaluated by an in vitro model of concanavalin A-induced mice splenocytes proliferation. Compound 1 showed significant inhibitory activity in a dose-dependent manner, closer to the efficacy of positive control, dexamethasone, at a concentration of 50 μM.

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