Chemical constituents from Gueldenstaedtia verna and their anti-inflammatory activity

Abstract

A new triterpenoid glycoside (1) and 15 known compounds (2–16) were isolated from the whole plants of Gueldenstaedtia verna. The new compound (1) was identified as complogenin 22-O-β-d-glucopyranoside by extensive spectroscopic techniques including 1D (¹H and ¹³C) and 2D NMR experiments (HSQC, HMBC and NOESY), HR-DART-MS and chemical methods. Most of the isolates were evaluated for their inhibitory activities on LPS-induced NO production in RAW 264.7 cells. The inhibitory effects of the active compounds, sulphuretin (8) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (13), on the production of pro-inflammatory mediators (including IL-6, IL1β and PGE₂) were further estimated in vitro by ELISA in RAW 264.7 macrophages.

Keywords:

• Gueldenstaedtia verna
• triterpenoid glycoside
• anti-inflammatory
• inhibition of NO production

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Corrigendum

Notes

This article was originally published with errors. This version has been corrected/amended. Please see Corrigendum at http://dx.doi.org/10.1080/14786419.2017.1405490