Spectroscopic characterisation of two polyketide metabolites from Cylindrocarpon sp. from driftwood

Abstract

Two new polyketides, (5R,7R,9R)-7,9-dihydroxy-5-decanolide and (4E,6R,9R)- 6,9-dihydroxydec-4-enoic acid (2), were isolated from rice cultures of Cylindrocarpon sp. SY-39 discovered during screening of driftwood at a Shonai coast area in Yamagata, Japan. The structures of 1 and 2 were determined using a variety of spectroscopic methods. Compound 2 exhibited moderate antimicrobial activity against Staphylococcus aureus NBRC 13276 and Aspergillus clavatus F 318a at a concentration of 50 μg per disk.

Keywords:

• Cylindrocarpon sp
• polyketides
• driftwood
• antimicrobial activity

Acknowledgements

We express our gratitude to Dr. Kenta Goto, Institute for Materials Chemistry and Engineering, Kyushu University, for supporting the measurement of the CD spectrum.