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Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 2
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Research Articles

15-deoxy-isoxeniolide-A, new diterpenoid from a bornean soft coral, Xenia sp.

Chin-Soon PhanLaboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Sabah, Malaysia
,
Takashi KamadaLaboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Sabah, Malaysia
,
Kazushi KobayashiGraduate School of Science and Engineering, Kagoshima University, Kagoshima, Japan
,
Toshiyuki HamadaGraduate School of Science and Engineering, Kagoshima University, Kagoshima, Japan
&
Charles Santhanaraju VairappanCorrespondence[email protected]
Pages 202-207 | Received 11 Feb 2017, Accepted 02 Jun 2017, Published online: 10 Jul 2017
 
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Abstract

A new xenicane diterpenoid, 15-deoxy-isoxeniolide-A (1) along with four known compounds 9-deoxy-isoxeniolide-A (2), isoxeniolide-A (3), xeniolide-A (4) and coraxeniolide-B (5) were isolated from the Bornean soft coral Xenia sp. The structures of these metabolites were elucidated on the basis of spectral analysis, NMR and HRESIMS. Compound 5 showed cytotoxic activity against ATL cell line, S1T.

Acknowledgement

The authors would like to acknowledge Prof Dr Tatsufumi Okino (Hokkaido University) for HRESIMS measurements and Takafumi Ishikawa (Hokkaido University) for SciFinder search.

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