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Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 16
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Research Articles

Chemical constituents from Curcuma longa L. and their inhibitory effects of nitric oxide production

Ting YuanKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Cuiyun ZhangKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Chongyue QiuKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Guiyang XiaKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Fei WangKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Bin LinKey Laboratory of Structure-Based Drug Design & Discovery, School of Pharmaceutical Engineering, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Hua LiKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence[email protected]
&
Lixia ChenKey Laboratory of Structure-Based Drug Design & Discovery, School of Traditional Chinese Materia Medica, Ministry of Education, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1887-1892 | Received 23 Mar 2017, Accepted 17 Jun 2017, Published online: 20 Jul 2017
 
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Abstract

A new bisabolane-type sesquiterpenoid, turmerone Q (1), along with six known compounds (2–7), were isolated from the rhizomes of Curcuma longa L. The structural elucidation of the new compound was conducted using 1H NMR, 13C NMR, HSQC, HMBC and NOESY spectroscopic analyses. The absolute configuration of 1 was elucidated by comparison of the experimental and calculated ECD spectra. The anti-inflammatory effects of 1–7 were evaluated through lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages assays, and compounds 6 and 7 showed potent inhibitory activity against NO production.

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