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Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 18
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Research Articles

Antioxidant acetophenone glycosides from the roots of Euphorbia ebracteolata Hayata

Anhua WangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
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Xiaoxv GaoSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;College of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
,
Xiaokui HuoCollege of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
,
Shanshan HuangCollege of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
,
Lei FengCollege of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
,
Chengpeng SunCollege of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
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Baojing ZhangCollege of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
,
Xiaochi MaCollege of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of China
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Jingming JiaSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]
&
Chao WangCollege of Pharmacy, Academy of Integrative Medicine, and Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 2187-2192 | Received 03 May 2017, Accepted 01 Aug 2017, Published online: 31 Aug 2017
 
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Abstract

A new acetophenone diglycoside, 2,4-dihydroxy-6-methoxy-3-methyl-acetophenone 4-O-gentiobioside (1), along with six know analogues (2–6), were isolated from the roots of Euphorbia ebracteolata. The structures of these isolates were determined by UV, HRESIMS, 1D and 2D NMR spectral analyses. In addition, all acetophenones showed moderate DPPH free radical scavenging capability, and no cytotoxicity against five human cancer cell lines.

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