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Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 8
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Research Article

A new pair of enantiomeric lignans from the fruits of Morinda citrifolia and their absolute configuration

Wen-Jian LiuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China
,
Yue-Juan ChenSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China
,
Dan-Na ChenSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China
,
Ya-Ping WuSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China
,
Yu-Jie GaoSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China
,
Jing LiSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China
,
Wen-Jun ZhongSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. China
&
Lin JiangSchool of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P. R. ChinaCorrespondence[email protected]
 show all
Pages 933-938 | Received 27 Jun 2017, Accepted 18 Aug 2017, Published online: 07 Sep 2017
 
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Abstract

A new pair of sesamin-type lignan enantiomers (±)-morifolia A (1a/1b) together with eight known analogues (2–9) were isolated from the fruits of Morinda citrifolia. Their structures were established by spectroscopic data and the absolute configurations of 1a/1b were determined by ECD calculation. All compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages, and compounds 1a, 1b, 2–4 and 7–9 exhibited pronounced inhibition with IC50 values in the range of 1.97–8.01 (μM, being more active than the positive control, quercetin (IC50 = 15.32 (M).

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