A new 2-alkylhydroquinone glucoside from Phagnalon saxatile (L.) Cass

Abstract

A new 2-alkylhydroquinone glucoside, 1-O-β-d-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl)benzene (1), in addition to nine known compounds were isolated from the aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae). Their structures were identified based on spectroscopic methods including 1D and 2D NMR, mass spectrometry (HR-ESI-MS), UV spectral analyses and by comparison with literature data. The cytotoxic activity of three isolated compounds (1–3) was evaluated against fibrosarcoma (HT1080), human lung cancer (A549) and breast cancer (MCF7) cell lines.

Keywords:

• Phagnalon saxatile (L.) Cass
• Asteraceae
• alkylhydroquinone glucoside
• cytotoxic activity

Acknowledgements

The authors are grateful to DGRSDT-MESRS (Algeria), for financial support and the Groupe Isolement et Structure of the Institut de Chimie Moleculaire de Reims (France) for technical help and registering of NMR data and MS.