Anti-inflammatory effect of ethanolic extract of spine, skin and rind of Jack fruit peel – A comparative study

Abstract

The present study was conducted to identify the chemical constituents and evaluate the anti-inflammatory activity of crude ethanolic extracts of spine, skin and rind of jack fruit (Artocarpus heterophyllus) peel. Polyphenol and flavonoid contents were assessed using Folin’s Ciocalteu reagent and aluminium chloride methods which revealed 316, 355 and 382 mg tannic acid equivalent/g of polyphenol and 96.7, 131.6 and 164.6 mg quercetin equivalent/g of flavonoid in spine, skin and rind, respectively. Anti-inflammatory activity of all three extracts was comparable to diclofenac in vitro and in vivo studies. Skin exhibited maximum anti-inflammatory activity, rind had preferential inhibition on Cyclooxygenase-2 and spine and skin inhibited both Cyclooxygenase-1 and 2 in vitro.

Keywords:

• Artocarpus heterophyllus
• polyphenols
• COX-1
• COX-2
• anti-inflammatory
• peel extract

Acknowledgements

The first author is thankful to Chettinad Academy of Research and Education for granting the Junior Research Fellowship and providing with necessary infrastructure. The authors thankfully acknowledge Dr. R. Murugaesan, IIT-Madras for providing the GC-MS facility and Cayman chemicals, Michigan, USA for supplying the COX activity kit.