Abstract
In the present study, biological activity and chemical composition of two crude extracts of endophytic fungal strains of Bipolaris genera isolated from two species of aquatic macrophytes: Eichhornia azurea (Kunth) and Eichhornia crassipes (Mart.) were investigated. The nuclear magnetic resonance and mass spectrometry data provided the identification of three main compounds: curvulin (1), spirostaphylotrichin R (2) and U (3). The fragmentation mechanism of the precursor ions towards collision induced dissociation (CID) tandem mass spectrometry experiment (MS/MS) is also proposed. Furthermore, biological screening of the crude extracts displayed antileishmanial activity with IC50 values ranging from 70–84.2 μg.mL−1.
Acknowledgements
The authors wish to thank Complexo Central de Apoio à Pesquisa (COMCAP/UEM), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for granting the scholarship and CNPq and Fundação Araucária (FA) for financial support.