A new dolabellane diterpene and a new polyacetylene from the soft coral Clavularia viridis

Abstract

A new dolabellane diterpene (1) and a new polyacetylene (2) were isolated from the soft coral Clavularia viridis. The structures of 1 and 2 were elucidated by spectroscopic analyses including 1D and 2DNMR experiments and HRESIMS data. The absolute configuration of 1 was determined by the modified Mosher’s method and 2 by ECD calculations. Compound 1 exhibited moderate cytotoxicities against MCF-7 and A549 cell lines with IC₅₀ values of 10.5 and 12.6 µM, respectively.

Keywords:

• Dolabellane diterpene
• polyacetylene
• Clavularia viridis
• cytotoxicity