Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral Sinularia erecta

Abstract

Using various chromatographic separations, eight sesquiterpenoids (1–8), including one new compound 3β,5α-dihydroxyeudesma-4(15),11-diene (1), were isolated from the MeOH extract of the Vietnamese soft coral Sinularia erecta. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound 1 exhibited selective cytotoxicity against the A549 cell line with IC₅₀ of 14.79 ± 0.91 μM.

Keywords:

• Sinularia erecta
• sesquiterpenoid
• eudesmane
• aromadendrane
• cytotoxicity

Acknowledgements

The authors are grateful to the Institute of Chemistry, VAST for measurement of the NMR spectra.