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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 5
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Research Articles

Polyphenolic characterisation of plant mixture (Lisosan® Reduction) and its hypocholesterolaemic effect in high fat diet-fed mice

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Pages 651-658 | Received 17 Oct 2017, Accepted 30 Oct 2017, Published online: 15 Nov 2017
 

Abstract

Lisosan® Reduction is a plant mixture produced from powder of fermented Triticum aestivum (Lisosan® G), Desmodium adscendens, Malus domestica, Picrorhiza kurroa and Hordeum vulgare. The aim of this study was to characterise the phenolic profile of Lisosan® Reduction and to evaluate the effects of aqueous extract on mice fed a high fat diet (HFD). Syringic acid, trans sinapic acid and neochlorogenic acid were identified by HPLC-DAD to be the dominant polyphenols of Lisosan® Reduction, followed by vitexin, trans p-coumeric acid and trans ferulic acid. Mice treated with aqueous extract of Lisosan® Reduction (60 mg/kg b.w.) showed a significant decrease of serum cholesterol, glucose and triglycerides level and a significant increase of CYP7A1 gene expression, compared to HFD group.

Acknowledgements

The authors gratefully thank M. Maltinti (Fondazione Toscana Gabriele Monasterio, Pisa, Italy) for plasma analysis, and Agrisan srl (Larciano, Pistoia, Italy) to supply us Lisosan® Reduction.

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