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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 6
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Short Communication

Alkaloids from Juglans Mandshurica maxim induce distinctive cell death in hepatocellular carcinoma cells

Li-Li LouSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Zhuo-Yang ChengSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Rui GuoSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Guo-Dong YaoSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]
&
Shao-Jiang SongSchool of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]
Pages 911-914 | Received 12 Nov 2017, Accepted 02 Dec 2017, Published online: 15 Dec 2017
 
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Abstract

The aim of this work was to further investigate the anticancer potential of Juglans mandshurica Maxim, including the separation of active constituents and their anti-proliferative effects with underlying mechanism of action. Five alkaloids (1–5) were isolated from the bark of J. mandshurica. Among them, 1 showed the highest cytotoxic activities against Hep3B and HepG2 cells with an IC50 values of 61.80 and 56.24 μM, respectively. Therefore, the cellular mechanism involved 1 was subsequently studied. Our results showed that 1 markedly caused apoptosis and autophagy, but without cell cycle arrest in HepG2 cells. Interestingly, only autophagic cell death was induced in 1-treated Hep3B cells. It is concluded that the isolated alkaloids exerted a certain anti-hepatoma potential, and our results may provide a basis for the further investigation of the alkaloids extracted from J. mandshurica.

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