Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 11
246
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Steroids from herbs of Reineckia carnea and their anticomplement activities

, , , , , & show all
Pages 1570-1576 | Received 09 Nov 2017, Accepted 26 Dec 2017, Published online: 15 Jan 2018
 

Abstract

A new polyhydroxylated pregnane, named lβ,2β,3β,4β,5β,6β-hexolhydroxy-pregn-16-en-20-one (1), along with nine known (2–10) steroidal saponins were isolated from the whole plant of Reineckia carnea. Structure elucidations of all compounds were established by interpretation of their NMR spectral data, HR-ESI-MS and comparing with literatures. In addition, these compounds were evaluated with anticomplement activity. The result showed that compound 1 exhibited anticomplement effects with the CH50 values of 0.043 mg/mL, but saponins (210) showed no inhibition. Interestingly, hydrolysis of steroidal saponins (210) resulted in its aglycones (2a10a) correspondingly which showed anticomplement activity with the CH50 values of 0.049–0.156 mg/mL.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.