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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 11
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Research Articles

Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

Xiaoshu ZhangSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Guohui ShiSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Mingbing LiuSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Rong ChenSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
,
Xiaojun WuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
&
Yuqing ZhaoSchool of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence[email protected]
Pages 1605-1611 | Received 09 Nov 2017, Accepted 10 Jan 2018, Published online: 23 Jan 2018
 
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Abstract

Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1), Gypensapogenin V (2), Gypensapogenin W (3) and Gypensapogenin X (4). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H2O2 and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated.

Acknowledgements

We are glad to acknowledge the Analytical Center of Shenyang Pharmaceutical University for NMR measurements.

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