Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 12
Submit an article Journal homepage
221
Views
3
CrossRef citations to date
0
Altmetric
Short Communication

Saponin-rich fraction from Agave sisalana: effect against malignant astrocytic cells and its chemical characterisation by ESI-MS/MS

João Victor A. de OliveiraLaboratório de Neuroquímica e Biologia Celular, Departamento de Bioquímica e Biofísica, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
,
Mariana B. BoturaDepartamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, BrazilCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6404-0314
ORCID Icon,
Jener D. G. dos SantosDepartamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, Brazil
,
Deivison S. ArgoloLaboratório de Neuroquímica e Biologia Celular, Departamento de Bioquímica e Biofísica, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
,
Victor Diogenes A. da SilvaLaboratório de Neuroquímica e Biologia Celular, Departamento de Bioquímica e Biofísica, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
,
Gisele D. da SilvaDepartamento de Patologias e Clínicas, Escola de Medicina Veterinária, Universidade Federal da Bahia, Salvador, Brazil
,
Hélimar G. de LimaDepartamento de Patologias e Clínicas, Escola de Medicina Veterinária, Universidade Federal da Bahia, Salvador, Brazil
,
Raimundo Braz FilhoLCQUI – CCT, Universidade Estadual do Norte Fluminense, Campos dos Goitacazes, Brazil;RJ/DEQUIM – ICE, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil
,
Ivo Jose C. VieiraLCQUI – CCT, Universidade Estadual do Norte Fluminense, Campos dos Goitacazes, Brazil;RJ/DEQUIM – ICE, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil
,
Alexsandro BrancoDepartamento de Saúde, Universidade Estadual de Feira de Santana, Feira de Santana, Brazil
,
Maria José M. BatatinhaDepartamento de Patologias e Clínicas, Escola de Medicina Veterinária, Universidade Federal da Bahia, Salvador, Brazil
&
Silvia L. CostaLaboratório de Neuroquímica e Biologia Celular, Departamento de Bioquímica e Biofísica, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
 show all
Pages 1769-1772 | Received 29 Oct 2017, Accepted 25 Jan 2018, Published online: 02 Feb 2018
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Astrocytic tumour cells derived from human (GL-15) and rat (C6) gliomas, as well as non-tumoural astrocytic cells, were exposed to the saponin-rich fraction (SF) from Agave sisalana waste and the cytotoxic effects were evaluated. Cytotoxicity assays revealed a reduction of cell viability that was more intensive in glioma than in non-tumoural cells. The SF induced morphological changes in C6 cells. They were characterised by cytoplasmic vacuole formation associated with increase in the formation of acidic lysosomes. The SF was subjected to purification on Sephadex LH-20, which characterised three probable steroidal saponins (sisalins) by electrospray ionisation mass spectrometry multistage (ESI-MSn). Sisalins from sisal may be responsible for the cytotoxicity, which involves cytoplasmatic vacuole formation and selective action for glioma cells.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.