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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 3
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Research Articles

A new tremulane sesquiterpenoid from the fungus Irpex lacteus

Jian-Hai DingEngineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, PR China;School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, PR China
,
Zheng-Hui LiSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, PR China
,
Tao FengSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, PR ChinaCorrespondence[email protected]
&
Ji-Kai LiuSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, PR ChinaCorrespondence[email protected]
Pages 316-320 | Received 26 Jan 2018, Accepted 02 Mar 2018, Published online: 09 Mar 2018
 
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Abstract

A new tremulane sesquiterpenoid, named irlactam A (1), was isolated from cultures of the fungus Irpex lacteus. The new structure was elucidated by spectroscopic data analysis. The compound was tested for its cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells and for its inhibitory activity against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD).

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