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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 3
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Research Articles

A new β-tetralonyl glucoside from the Santalum album derived endophytic fungus Colletotrichum sp. GDMU-1

Weiyang LiuSchool of Pharmacy, Guangdong Medical University, Dongguan, China
,
Senhua ChenSchool of Marine Sciences, Sun Yat-Sen University, Guangzhou, China
,
Jing LiSchool of Pharmacy, Guangdong Medical University, Dongguan, China
,
Xuemei YangSchool of Pharmacy, Guangdong Medical University, Dongguan, China
,
Chong YanSchool of Pharmacy, Guangdong Medical University, Dongguan, ChinaCorrespondence[email protected]
&
Hongju LiuSchool of Pharmacy, Guangdong Medical University, Dongguan, ChinaCorrespondence[email protected]
Pages 354-359 | Received 01 Nov 2017, Accepted 10 Mar 2018, Published online: 19 Mar 2018
 
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Abstract

A new β-tetralonyl glucoside, methylberchemiaside (1), along with five known compounds (2–6) were isolated from a fungus Colletotrichum sp. GDMU-1 derived from the leaves of Santalum album. Their structures were determined by detailed analysis of spectroscopic data. All compounds were tested for the inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-treated RAW264.7 cells. Among them, compounds 4 and 5 showed moderate anti-inflammatory activity with IC50 value of 30.4 and 8.9 μM, respectively.

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