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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 17
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Research Articles

Two new labdane diterpenoids from aerial parts of Leonurus japonicus and their anti-inflammatory activity

Yu-Mei HuJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, PR China;Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China;Jiangsu Botanical Medicine Refine Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing, PR China
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Wen-Jun LiuJiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China
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Meng-Xuan LiJiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China
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Hai-Bo LiJiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China
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Tao JiangJiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China
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Ning-Bo ChengJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, PR China;Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China
,
Wen-Zhe HuangJiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China
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Zhen-Zhong WangJiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR China
,
Hua-Xu ZhuJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, PR China;Jiangsu Botanical Medicine Refine Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing, PR ChinaCorrespondence[email protected]
&
Wei XiaoJiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, PR China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, PR ChinaCorrespondence[email protected]
 show all
Pages 2490-2497 | Received 21 Sep 2017, Accepted 17 Mar 2018, Published online: 09 Apr 2018
 
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Abstract

Two new labdane diterpenoids, Leojaponin E (1) and F (2), together with three known compounds were isolated from the dried herb of Leonurus japonicus Houtt., Lamiaceae. Their structures were determined based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. In addition, compounds 1 and 2 exerted inhibition of LPS-induced PGE2 production in a dose-dependent manner at concentrations ranging from 5 to 20 μM.

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