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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 3
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Research Articles

Macrocyclic bis-quinolizidine alkaloids from Xestospongia muta

Duong Thi DungInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Dan Thi Thuy HangInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Pham Hai YenInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Tran Hong QuangInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Nguyen Xuan NhiemInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Bui Huu TaiInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Chau Van MinhInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam
,
Youn-Chul KimCollege of Pharmacy, Wonkwang University, Iksan, Korea
,
Dong Cheol KimCollege of Pharmacy, Wonkwang University, Iksan, Korea
,
Hyuncheol OhCollege of Pharmacy, Wonkwang University, Iksan, Korea
&
Phan Van KiemInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam;Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, VietnamCorrespondence[email protected]
 show all
Pages 400-406 | Received 07 Jan 2018, Accepted 17 Mar 2018, Published online: 29 Mar 2018
 
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Abstract

A new stereoisomer Meso-araguspongine C together with nine reported macrocyclic bis-quinolizidine alkaloids araguspongines A, C, E, L, N−P, petrosin, and petrosin A were isolated from marine sponge Xestospongia muta. Stereochemistry of meso-araguspongine C (2) and araguspongines N-P (3−5) were established by their NMR data and conformational analyses. Both araguspongine C (1) and meso-araguspongine C (2) exhibited great cytotoxic activity towards HepG-2, HL-60, LU-1, MCF-7, and SK-Mel-2 human cancer cells (IC50 in the range of 0.43–1.02 μM). At a concentration of 20 μM, isolated compounds (1−10) also showed modest inhibitory effects (from 7.6 to 40.8%) on the NO production in LPS activated RAW264.7 macrophages.

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